For most blood group antigens, serologic testing reveals RBCs to be either positive or negative for the D antigen and any discrepancy is usually related to sample or recording errors. However, the complexity of D antigen expression has led to confusion and inconsistency in transfusion medicine practice. Additionally, the complexity of Rh system typing and genetics leads to confusion among clinicians.
If you're looking for some clarity around this complex issue, fill out the form to download this “How do I,” which appeared in Transfusion, for more discussion on the current Beth Israel Deaconess Medical Center (BIDMC) approach to D typing in obstetric (OB) patients to resolve typing discrepancies. Dr. Richard L. Haspel and NYBC's Dr. Connie M. Westhoff also assess the need for RhIG prophylaxis and decide on appropriate RBC products for transfusion.