Download one of NYBCe's COVID-19 Related Research Projects

NYBCe and its research division, Lindsley F. Kimball Research Institute, like many research institutions around the world, has focused much of its attention on investigating and developing solutions for the COVID-19 pandemic, gathering and publishing vast amounts of data.

Fill out the form below to access NYBCe's COVID-19 related research papers. Summaries of all seven papers are available below the form. "CTRL + Click" to select more than one paper.

 

 

 

Paper #1: Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses.

Authors: Shibo Jiang, Christopher Hillyer & Lanying Du

Journal: Trends in Immunology.

Description: A discussion of efforts to isolate SARS-CoV-2 neutralizing antibodies, which would inactivate the virus, including the potential of polyclonal antibodies obtained from the blood plasma of convalesced COVID-19 patients. This paper includes a comparison of potentially cross-reactive neutralizing antibodies known to target SARS-CoV and MERS-CoV.

 

Paper #2: Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: Implication for development of RBD protein as a viral attachment inhibitor and vaccine.

Authors: Wanbo Tai, Xiujuan Zhang, Jing Pu, Denis Voronin, Shibo Jiang, Yusen Zhou & Lanying Du.

Journal: Cellular & Molecular Immunology.

Description: The spike proteins of both SARS-CoV, which causes SARS, and SARS-CoV-2, which causes COVID-19, show a binding affinity for the ACE2 receptor, which allows them to enter and infect cells. This paper discusses the capabilities of using a SARS-CoV-based vaccine to inhibit SARS-CoV-2 from binding to ACE2 receptors and causing infection.

 

Paper #3: Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry.

Authors: Yushun Wan, Jian Shang, Shihui Sun, Wanbo Tai, Jing Chen, Qibin Geng, Lei He, Yuehong Chen, Jianming Wu, Zhengli Shi, Yusen Zhou, Lanying Du & Fang Li.

Journal: Journal of Virology.

Description: Antibody-Dependent Enhancement (ADE) is a phenomenon in which antibodies that completely neutralize one serotype of a virus but only subneutralize another serotype can mediate viral entry and worsen infection of the second serotype. This paper explores the molecular mechanisms of ADE of a monoclonal antibody on MERS-CoV, potentially guiding future vaccination and antiviral treatment strategies.

 

Paper #4: The Adjuvanticity of an O. volvulus-Derived rOv-ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human Primates.

Authors: Jing Wang, Nancy Tricoche, Lanying Du, Meredith Hunter, Bin Zhan, Gaddam Goud, Elizabeth S. Didier, Jing Liu, Lu Lu, Preston A. Marx, Shibo Jiang & Sara Lustigman.

Journal: PLoS One.

Description: This paper describes the potential of a protein derived from the nematode Onchocerca volvulus to be used as a vaccine adjuvant, a substance that amplifies immune system activity, making a vaccine more effective while using smaller antigen doses.

 

Paper #5: Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses.

Authors: Ning Wang, Jian Shang, Shibo Jiang, & Lanying Du.

Journal: Frontiers in Microbiology.

Description: A review that includes descriptions of the structure and function of key proteins in SARS-CoV, MERS-CoV, and SARS-CoV-2, such as the spike protein, as well as an evaluation of current efforts to develop subunit vaccines, which contain key protein fragments of the pathogenic viruses instead of whole-pathogen or nucleic-acid vaccines.

 

Paper #6: Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.

Authors: Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu, Chuan Qin, Fei Sun, Zhengli Shi, Yun Zhu, Shibo Jiang & Lu Lu.

Journal: Cell Research.

Description: The researchers developed and tested derivations of a pan-coronavirus fusion inhibitor shown to suppress infection by preventing the fusion of the membranes of virus and host cells in SARS-CoV and MERS-CoV. Administration of the inhibitor in mice also prevented coronavirus infections from developing.

 

Paper #7: Current development of COVID-19 diagnostics, vaccines and therapeutics.

Authors: Naru Zhang, Chaoqun Li, Yue Hu, Kangchen Li, Jintian Liang, Lili Wang, Lanying Du & Shibo Jiang.

Journal: Microbes and Infection.

Description: A review of current and developing strategies for diagnosis, vaccines in development, and therapeutics for COVID-19.